PhD in Statistics

Topic: “Bayesian Modelling of Functional Data”.

University of Kent, Supervisor: Prof. Phil Brown

Athens University of Economics and Business

Department of Statistics, Scholarship for 3 years

Participated in the Erasmus programme

University of Sheffield, UK

Department of Probability and Statistics

Duties at UCB (July 2011 – present): Early phase trial statistician and pre-clinical statistical support.

Pharmacokinetics modelling, Bayesian PK modelling, modelling and simulation, adaptive designs, design and analysis of drug – to -drug interaction studies and first in human studies, gene expression data analysis and sample sizing approaches.

Subject matter expert in Bayesian design and analysis of early phase studies.

Therapeutic areas: Central nervous system (CNS) and Immunology

Postdoctoral Research Statistician at Pfizer Pharmaceutical (Non – Clinical statistics)

Duties: Platform line support, development of novel methodologies for the analysis of EEG data, microarray data analysis, multivariate analysis, design and analysis of experiments.

Study analysis, and reporting of regulatory studies in Drug Safety R&D, including safety pharmacology, abuse potential and drug discrimination studies. Work on translatable biomarkers (in vivo), e.g. EEG data and ocular endpoints analysis. Collaborations with computational chemists. Work in respiratory therapeutic area e.g. analysing COPD (Chronic Obstructive Pulmonary Disease) data. Pharmacodynamics modelling, in particular develop models for estimating the intrinsic clearance. Analysis of data coming from the comparative medicine unit.

Internship at Citibank, 54 Syngrou Ave, Athens, Greece.

Duties: Statistical analysis, research on Value at Risk, selection of the optimum portfolio.

“Handling missing data in clinical development”, Journal of Pharmaceutical statistics, T. Mutsvari, F. Strimenopoulou and C. Otoul. (To be submitted)

“Extracting drug mechanism and pharmacody namic information from clinical electroencephalography data using generalised semi- linear canonical correlation analysis”, P Brain, F Strimenopoulou, A Diukova, E Berry, A Jolly, JE Hall, R G Wise, M Ivarsson, F J Wilson, Physiol. Meas. 35 (2014) 2459-2474.

Generalised semi – linear canonical correlation analysis applied to the analysis of electroencephalogram (EEG) data”, P. Brain, M. Ivarsson and F. Strimenopoulou. Stat. Biopharm. Res. 4  49 – 161, R package developed.

“Mass spectra analysis through penalized logistic regression and functional mixed effect modelling”, F. Strimenopoulou and P.J. Brown, ISI proceedings 2009,

“Empirical Bayes logistic regression analysis”, F. Strimenopoulou and P.J. Brown, Statistical Applications in Genetics and Molecular Biology, Vol. 7, Issue 4, Article 9,

Talk: “Implementing Bayesian methods in early clinical development at UCB”, European statistical

forum 2014, Brussels, Belgium

Talk: “Clinical and pre-clinical applications of Bayesian methods at UCB”, co-presenter: Ros Walley, Bayes – Pharma 2012, University College London, UK.

Poster: “ Robust Bayesian functional mixed effects modelling”, Ninth Valencia International Meeting on Bayesian Statistics & 2010 ISBA World Meeting, Benidorm, Spain.

Talk : “Mass spectra analysis through penalized logistic regression and functional mixed effect modelling”, Invited Paper Meeting, 57th Session of the International Statistical Institute, Durban, South Africa.

Poster: “Generalized Wavelet functional mixed model”, UK Statistical and Programming Annual Meeting, GSK Stockley Park, UK.

Talk: “Bayesian functional data analysis”, Research Student Seminar, IMSAS, University of Kent, UK.

Poster: “Gaussian mixtures in Mass-Spectra”, Research Student Conference, University of Nottingham, UK.

Talk: “Bayesian feature selection in functional data”, Research Student Seminar, IMSAS, University of Kent, UK.

Poster: “Clinical mass-spectrometry proteomic diagnosis”, Cancer Informatics, CBMI Annual symposium. University of Kent, UK.

Talk: “Clinical mass-spectrometry proteomic diagnosis” (with Phil Brown), Leiden University, Netherlands.

“Bayesian Inference in High Dimensions”, LTCC, London, UK.

“Graduate training course in mathematical statistics and in applied probability”, Royal Statistical Society, University College London, UK.